Studies of Binding of Testosterone-estradiol Binding Globulin for Estradiol-17β
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چکیده
منابع مشابه
Investigation of Sex-Hormone Binding Globulin for Testosterone and Estradiol
The aim of this study was to find reasons for the interference of sex-hormone binding globulin (SHBG) in direct radloimmunoassays (RIAs) for testosterone and estradiol. 1251.. labeled testosterone and estradiol were compared with 3Hlabeled testosterone and estradiol for their affinity to SHBG. The 3H-Iabeled steroids bound far more avidly to SHBG than did the corresponding 1251-labeled steroids...
متن کاملSubunit structure of rabbit testosterone estradiol-binding globulin.
Testosterone estradiol-binding globulin (rbTeBG) of rabbit plasma was purified to homogeneity by the sequential use of ammonium sulfate precipitation, affinity chromatography on 5 alpha-dihydrotestosterone-Sepharose, reactive blue-Sepharose, and finally preparative polyacrylamide gel electrophoresis. An overall purification of greater than 3000-fold was achieved with a recovery of 32%. This pur...
متن کاملSubunit Structure of Rabbit Testosterone Estradiol-binding Globulin*
Testosterone estradiol-binding globulin (rbTeBG) of rabbit plasma was purified to homogeneity by the sequential use of ammonium sulfate precipitation, affinity chromatography on 5a-dihydrotestosterone-Sepharose, reactive blue-Sepharose, and finally preparative polyacrylamide gel electrophoresis. An overall purification of greater than 3000-fold was achieved with a recovery of 32%. This purified...
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Although 17β-estradiol (E2) is a natural molecule involved in the endocrine system, its widespread use in various applications has resulted in its accumulation in the environment and its classification as an endocrine-disrupting molecule. These molecules can interfere with the hormonal system, and have been linked to various adverse effects such as the proliferation of breast cancer. It has bee...
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Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker effect with present sample sizes is limited. An alternative approach is to look for variants associated with quantitative traits that in turn affect disease risk. As exposure...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1976
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.52.3_189